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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2388061Generated: November 1, 2026

2-Chloro-4-(trifluoromethyl)benzenesulfonyl chloride → 2-Chloro-N-(5-chloro-6-(isoquinolin-3-yloxy)pyridin-3-yl)-4(trifluoromethyl)benzene sulfonamide

https://huagongshe.com/reaction/2388061

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Chloro-4-(trifluoromethyl)benzenesulfonyl chlorideHCID 2736675—
Reactant5-Chloro-6-(isoquinolin-3-yloxy)pyridin-3-amineHCID 68793757—
Product2-Chloro-N-(5-chloro-6-(isoquinolin-3-yloxy)pyridin-3-yl)-4(trifluoromethyl)benzene sulfonamideHCID 24852476—

Reaction Steps

The title compound was prepared by reacting 5-chloro-6-(isoquinolin-3-yloxy)pyridin-3-amine (obtained as per procedure described in preparation 2) and 2-chloro-4-(trifluoromethyl)benzene-1-sulfonyl chloride.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08269010B2
Source datasetuspto-grants-2012_09
ORD IDord-12c11e3677a74ce98bb6939c725ff60e
Source noteuspto-grants-2012_09