3,4-Difluorobenzene-1-sulfonyl chloride → N-(5-Chloro-6-(quinolin-3-yloxy)pyridin-3-yl)-3,4-difluorobenzenesulfonamide

HRID 2388078Notes

Reaction equation

HRID 2388078 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([NH2:19])[CH:5]=[N:6][C:7]=1[O:8][C:9]1[CH:10]=[N:11][C:12]2[C:17]([CH:18]=1)=[CH:16][CH:15]=[CH:14][CH:13]=2.[F:20][C:21]1[CH:22]=[C:23]([S:28](Cl)(=[O:30])=[O:29])[CH:24]=[CH:25][C:26]=1[F:27]>>[Cl:1][C:2]1[CH:3]=[C:4]([NH:19][S:28]([C:23]2[CH:24]=[CH:25][C:26]([F:27])=[C:21]([F:20])[CH:22]=2)(=[O:30])=[O:29])[CH:5]=[N:6][C:7]=1[O:8][C:9]1[CH:10]=[N:11][C:12]2[C:17]([CH:18]=1)=[CH:16][CH:15]=[CH:14][CH:13]=2

Participants

3

Reactant 2

HCID 27369133,4-Difluorobenzene-1-sulfonyl chlorideHCID 687907985-Chloro-6-(quinolin-3-yloxy)pyridin-3-amine

Product 1

HCID 24852805N-(5-Chloro-6-(quinolin-3-yloxy)pyridin-3-yl)-3,4-difluorobenzenesulfonamide

Procedure

The title compound was prepared by reacting 5-chloro-6-(quinolin-3-yloxy)pyridin-3-amine (obtained as per procedure described in preparation 1) and 3,4-difluorobenzene-1-sulfonyl chloride.

Sources & evidence

ORD record
ord-c2a8a8e5459e4ecd888e4117f55682e0
Source dataset
uspto-grants-2012_09
Patent number
US08269010B2

Reaction notes

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