Benzenesulfonyl chloride → N-(5-Chloro-6-(quinolin-3-yloxy)pyridin-3-yl)benzenesulfonamide

HRID 2388085Notes

Reaction equation

HRID 2388085 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([NH2:19])[CH:5]=[N:6][C:7]=1[O:8][C:9]1[CH:10]=[N:11][C:12]2[C:17]([CH:18]=1)=[CH:16][CH:15]=[CH:14][CH:13]=2.[C:20]1([S:26](Cl)(=[O:28])=[O:27])[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1>>[Cl:1][C:2]1[CH:3]=[C:4]([NH:19][S:26]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)(=[O:28])=[O:27])[CH:5]=[N:6][C:7]=1[O:8][C:9]1[CH:10]=[N:11][C:12]2[C:17]([CH:18]=1)=[CH:16][CH:15]=[CH:14][CH:13]=2

Participants

3

Reactant 2

HCID 7369Benzenesulfonyl chlorideHCID 687907985-Chloro-6-(quinolin-3-yloxy)pyridin-3-amine

Product 1

HCID 24852920N-(5-Chloro-6-(quinolin-3-yloxy)pyridin-3-yl)benzenesulfonamide

Procedure

The title compound was prepared by reacting 5-chloro-6-(quinolin-3-yloxy)pyridin-3-amine (obtained as per procedure described in preparation 1) and benzenesulfonyl chloride. 1H NMR (DMSO-d6) δ: 7.57-7.76 (m, 9H), 7.92 (d, 1H), 8.01 (d, 1H), 8.15 (s, 1H), 8.77 (s, 1H), 10.59 (s, 1H); MS (ES): 411.99 (M+1).

Sources & evidence

ORD record
ord-352a541f0d2a458aadb6ed96005a75ce
Source dataset
uspto-grants-2012_09
Patent number
US08269010B2

Reaction notes

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