Tetraethyltin → 4-Ethyl-7-hydroxy-2-phenyl-oxazolo[4,5-c]pyridine-6-carboxylic acid methyl ester

HRID 2388139Notes

Reaction equation

HRID 2388139 reaction equation
[CH3:1][O:2][C:3]([C:5]1[N:10]=[C:9](Br)[C:8]2[N:12]=[C:13]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)[O:14][C:7]=2[C:6]=1[OH:21])=[O:4].[CH2:22]([Sn](CC)(CC)CC)[CH3:23]>>[CH3:1][O:2][C:3]([C:5]1[N:10]=[C:9]([CH2:22][CH3:23])[C:8]2[N:12]=[C:13]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)[O:14][C:7]=2[C:6]=1[OH:21])=[O:4]

Participants

3

Reactant 2

HCID 11704TetraethyltinHCID 866481114-Bromo-7-hydroxy-2-phenyl-oxazolo[4,5-c]pyridine-6-carboxylic acid methyl ester

Product 1

HCID 675293924-Ethyl-7-hydroxy-2-phenyl-oxazolo[4,5-c]pyridine-6-carboxylic acid methyl ester

Procedure

Prepared from 4-bromo-7-hydroxy-2-phenyl-oxazolo[4,5-c]pyridine-6-carboxylic acid methyl ester, example 3a, and tetraethyltin under conditions analogous to example 3b. MS: (+) m/z 299.1 (M+1).

Sources & evidence

ORD record
ord-498c23ec4298449c972e1116cc1ade53
Source dataset
uspto-grants-2012_09
Patent number
US08269008B2

Reaction notes

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