Tributyl(4-fluorophenyl)stannane → 4-(4-Fluoro-phenyl)-7-hydroxy-2-phenyl-oxazolo[4,5-c]pyridine-6-carboxylic acid methyl ester

HRID 2388142Notes

Reaction equation

HRID 2388142 reaction equation
[CH3:1][O:2][C:3]([C:5]1[N:10]=[C:9](Br)[C:8]2[N:12]=[C:13]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)[O:14][C:7]=2[C:6]=1[OH:21])=[O:4].C([Sn](CCCC)(CCCC)[C:27]1[CH:32]=[CH:31][C:30]([F:33])=[CH:29][CH:28]=1)CCC>>[CH3:1][O:2][C:3]([C:5]1[N:10]=[C:9]([C:27]2[CH:32]=[CH:31][C:30]([F:33])=[CH:29][CH:28]=2)[C:8]2[N:12]=[C:13]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)[O:14][C:7]=2[C:6]=1[OH:21])=[O:4]

Participants

3

Reactant 2

HCID 2737524Tributyl(4-fluorophenyl)stannaneHCID 866481114-Bromo-7-hydroxy-2-phenyl-oxazolo[4,5-c]pyridine-6-carboxylic acid methyl ester

Product 1

HCID 675298994-(4-Fluoro-phenyl)-7-hydroxy-2-phenyl-oxazolo[4,5-c]pyridine-6-carboxylic acid methyl ester

Procedure

Prepared from 4-bromo-7-hydroxy-2-phenyl-oxazolo[4,5-c]pyridine-6-carboxylic acid methyl ester, example 3a, and tributyl(4-fluorophenyl)stannane under conditions analogous to example A-3b. MS: (+) m/z 364.9 (M+1).

Sources & evidence

ORD record
ord-c45e418cd5f44e988e96ebf91209fd50
Source dataset
uspto-grants-2012_09
Patent number
US08269008B2

Reaction notes

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