Hydrochloric Acid → [(7-Hydroxy-3-phenyl-isoxazolo[4,5-c]pyridine-6-carbonyl)-amino]-acetic acid

Participants

Reaction Steps

Ethyl 7-hydroxy-3-phenylisoxazolo[4,5-c]pyridine-6-carboxylate (0.11 g, 0.39 mmol) was dissolved in 10 mL of DMF. Glycine (0.58 g, 7.75 mmol) and sodium ethoxide (0.40 g, 5.81 mmol) were added and the mixture was refluxed for 14 h. The mixture was cooled to room temperature and diluted with 60 mL of water. Concentrated hydrochloric acid was added dropwise until pH was 3. The resulting suspension was filtered and the solid was dried under vacuum to give 70 mg of the title compound. MS: (+) m/z 314.00 (M+1).

Provenance & Evidence