Benzoyl Peroxide → HCID 67529296, compound

Participants

Reaction Steps

Ethyl 3-(5-bromofuran-2-yl)-4-methylisoxazole-5-carboxylate (1.7 g, 5.67 mmol), NBS (1.2 g, 6.8 mmol), and benzoyl peroxide (0.14 g, 0.567 mmol) were added to 50 mL of carbon tetrachloride and the mixture was refluxed for 16 h. Reaction mixture was concentrated and purified by chromatography (0-30% EtOAc/hexanes) to give 1.8 g of the title compound along with small amount of unreacted starting material. 1H NMR (CDCl3, 200 MHz): δ=7.09 (d, 1H, J=3.4 Hz), 6.54 (d, 1H, J=3.6 Hz), 4.84 (s, 2H), 4.51 (q, 2H, J=7.0 Hz), 1.49 (t, 3H, J=7.4 Hz).

Provenance & Evidence