Hydrochloric Acid → HCID 42633063, compound

Participants

Reaction Steps

Ethyl 3-(5-bromofuran-2-yl)-7-hydroxyisoxazolo[4,5-c]pyridine-6-carboxylate (62 mg, 0.176 mmol) was dissolved in 10 mL of DMF. Glycine (0.264 g, 3.51 mmol) and sodium ethoxide (0.179 g, 2.63 mmol) were added and the mixture was refluxed for 3 h. The mixture was cooled to room temperature and diluted with 70 mL of water. Concentrated hydrochloric acid was added dropwise until pH was 3. The resulting suspension was filtered and the solid was dried under vacuum to give 62 mg of the title compound. MS: (+) m/z 382, 384 (M+1, 79Br/81Br).

Provenance & Evidence