Hydrochloric Acid → HCID 42633065, compound

Participants

Reaction Steps

Ethyl 4-cyano-7-hydroxy-3-(thiophen-2-yl)isoxazolo[4,5-c]pyridine-6-carboxylate (136 mg, 0.432 mmol) and glycine (648 mg, 8.63 mmol) were added to sodium methoxide solution (13 mL, 6.48 mmol, 0.5 M in MeOH) and the mixture was refluxed for 3 days. The mixture was cooled to room temperature and 0.25 M hydrochloric acid was added until pH was 3. The precipitate was isolated by filtration and dried under vacuum to give 101 mg of the title compound. MS: (−) m/z 343.28 (M−1).

Provenance & Evidence