Hydrochloric Acid → HCID 42633066, compound

Participants

Reaction Steps

Ethyl 4-cyano-3-(4-fluorophenyl)-7-hydroxyisoxazolo[4,5-c]pyridine-6-carboxylate (101 mg, 0.309 mmol) and glycine (468 mg, 6.18 mmol) were added to sodium methoxide solution (9.3 mL, 4.63 mmol, 0.5 M in MeOH) and the mixture was refluxed for 3 days. The mixture was cooled to room temperature and 0.25 M hydrochloric acid was added until pH was 3. The precipitate was isolated by filtration and dried under vacuum to give 73 mg of the title compound. MS: (−) m/z 355.31 (M−1).

Provenance & Evidence