Cesium carbonate → HCID 86648129, compound

Participants

Reaction Steps

Ethyl 7-hydroxy-3-phenyl-4-((trimethylsilyl)ethynyl)isoxazolo[4,5-c]pyridine-6-carboxylate (205 mg, 0.54 mmol) was dissolved in a 1:1 mixture of EtOH/CH2Cl2 (6 mL). Cesium carbonate (211 mg, 0.65 mmol) was added and the resulting slurry was stirred at room temperature for 14 h. The solvent was evaporated and the residue was partitioned between EtOAc (25 mL) and 1 M hydrochloric acid (25 mL). The aqueous layer was extracted with CH2Cl2 and the combined organic layer was dried over MgSO4 and concentrated to give 185 mg of the title compound. MS: (+) m/z 309.29 (M+1).

Provenance & Evidence