N-(azetidin-3-ylcarbamoylmethyl)-3-trifluoromethyl-benzamide → HCID 59541858, compound

HRID 2388302Notes

Reaction equation

HRID 2388302 reaction equation
[CH3:1][O:2][C:3]1[C:8]([C:9]2[CH2:14][CH2:13][C:12](=O)[CH2:11][CH:10]=2)=[CH:7][CH:6]=[CH:5][N:4]=1.[NH:16]1[CH2:19][CH:18]([NH:20][C:21]([CH2:23][NH:24][C:25](=[O:36])[C:26]2[CH:31]=[CH:30][CH:29]=[C:28]([C:32]([F:35])([F:34])[F:33])[CH:27]=2)=[O:22])[CH2:17]1>>[CH3:1][O:2][C:3]1[C:8]([C:9]2[CH2:14][CH2:13][CH:12]([N:16]3[CH2:19][CH:18]([NH:20][C:21]([CH2:23][NH:24][C:25](=[O:36])[C:26]4[CH:31]=[CH:30][CH:29]=[C:28]([C:32]([F:35])([F:33])[F:34])[CH:27]=4)=[O:22])[CH2:17]3)[CH2:11][CH:10]=2)=[CH:7][CH:6]=[CH:5][N:4]=1

Participants

3

Reactant 2

HCID 59361594N-(azetidin-3-ylcarbamoylmethyl)-3-trifluoromethyl-benzamideHCID 59541849HCID 59541849, compound

Product 1

HCID 59541858HCID 59541858, compound

Procedure

The title compound was prepared as a white solid from reductive amination of 4-(2-methoxy-pyridin-3-yl)-cyclohex-3-enone (as prepared in the previous step) and N-(azetidin-3-ylcarbamoylmethyl)-3-trifluoromethyl-benzamide using the procedure described in Step F of Example 1.

Sources & evidence

ORD record
ord-39211e94ed574d609a356b2e939ae27a
Source dataset
uspto-grants-2012_09
Patent number
US08269015B2

Reaction notes

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