HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(3-Hydroxy-pyridin-2-yl)-cyclohexanone → N-({1-[4-(3-Hydroxy-pyridin-2-yl)-cyclohexyl]-azetidin-3-ylcarbamoyl}-methyl)-3-trifluoromethyl-benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(3-Hydroxy-pyridin-2-yl)-cyclohexanone | HCID 58562633 | — |
| Reactant | N-(azetidin-3-ylcarbamoylmethyl)-3-trifluoromethyl-benzamide | HCID 59361594 | — |
| Product | N-({1-[4-(3-Hydroxy-pyridin-2-yl)-cyclohexyl]-azetidin-3-ylcarbamoyl}-methyl)-3-trifluoromethyl-benzamide | HCID 46947815 | — |
Reaction Steps
The title compounds were prepared as white solids from the reductive amination of 4-(3-hydroxy-pyridin-2-yl)-cyclohexanone (as prepared in the previous step) and N-(azetidin-3-ylcarbamoylmethyl)-3-trifluoromethyl-benzamide using the procedure described in Step F of Example 1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08269015B2 |
| Source dataset | uspto-grants-2012_09 |
| ORD ID | ord-6d3eb61d7f584c35b889ad5671032fde |
| Source note | uspto-grants-2012_09 |