N-(azetidin-3-ylcarbamoylmethyl)-3-trifluoromethyl-benzamide → HCID 178521348, compound

HRID 2388306Notes

Reaction equation

HRID 2388306 reaction equation
[OH:1][C:2]1[C:7]([CH:8]2[CH2:13][CH2:12][C:11](=O)[CH2:10][CH2:9]2)=[CH:6][CH:5]=[CH:4][N:3]=1.[NH:15]1[CH2:18][CH:17]([NH:19][C:20]([CH2:22][NH:23][C:24](=[O:35])[C:25]2[CH:30]=[CH:29][CH:28]=[C:27]([C:31]([F:34])([F:33])[F:32])[CH:26]=2)=[O:21])[CH2:16]1>>[OH:1][C:2]1[C:7]([CH:8]2[CH2:13][CH2:12][CH:11]([N:15]3[CH2:18][CH:17]([NH:19][C:20]([CH2:22][NH:23][C:24](=[O:35])[C:25]4[CH:30]=[CH:29][CH:28]=[C:27]([C:31]([F:34])([F:32])[F:33])[CH:26]=4)=[O:21])[CH2:16]3)[CH2:10][CH2:9]2)=[CH:6][CH:5]=[CH:4][N:3]=1

Participants

3

Reactant 2

HCID 59361594N-(azetidin-3-ylcarbamoylmethyl)-3-trifluoromethyl-benzamideHCID 178515867HCID 178515867, compound

Product 1

HCID 178521348HCID 178521348, compound

Procedure

The title compounds were prepared as white solids from the reductive amination of 4-(2-hydroxy-pyridin-3-yl)-cyclohexanone (as prepared in the previous step) and N-(azetidin-3-ylcarbamoylmethyl)-3-trifluoromethyl-benzamide using the procedure described in Step F of Example 1.

Sources & evidence

ORD record
ord-7f19b5f3674b4d8683921f5a13187461
Source dataset
uspto-grants-2012_09
Patent number
US08269015B2

Reaction notes

Loading…