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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2388312Generated: November 3, 2026

N-(azetidin-3-ylcarbamoylmethyl)-3-trifluoromethyl-benzamide → N-({1-[4-(6-Amino-pyridin-2-yl)-cyclohexyl]-azetidin-3-ylcarbamoyl}-methyl)-3-trifluoromethyl-benzamide

https://huagongshe.com/reaction/2388312

Reaction equation

Participants

RoleNameHCIDCharge
ReactantN-(azetidin-3-ylcarbamoylmethyl)-3-trifluoromethyl-benzamideHCID 59361594—
ReactantHCID 59541848HCID 59541848—
ProductN-({1-[4-(6-Amino-pyridin-2-yl)-cyclohexyl]-azetidin-3-ylcarbamoyl}-methyl)-3-trifluoromethyl-benzamideHCID 46945437—

Reaction Steps

The title compounds were prepared as white solids from the reductive amination of 4-(6-amino-pyridin-2-yl)-cyclohexanone (as prepared in the previous step) and N-(azetidin-3-ylcarbamoylmethyl)-3-trifluoromethyl-benzamide using the procedure described in Step F of Example 1.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08269015B2
Source datasetuspto-grants-2012_09
ORD IDord-785a944c15d444278009d9c0ffe3b68b
Source noteuspto-grants-2012_09