HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 59541848, compound → N-({1-[4-(6-Amino-pyridin-2-yl)-cyclohexyl]-azetidin-3-ylcarbamoyl}-methyl)-4-fluoro-3-trifluoromethyl-benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 59541848 | HCID 59541848 | — |
| Reactant | N-(azetidin-3-ylcarbamoylmethyl)-4-fluoro-3-trifluoromethyl-benzamide | HCID 59541942 | — |
| Product | N-({1-[4-(6-Amino-pyridin-2-yl)-cyclohexyl]-azetidin-3-ylcarbamoyl}-methyl)-4-fluoro-3-trifluoromethyl-benzamide | HCID 46945645 | — |
Reaction Steps
The title compounds were prepared as white solids from the reductive amination of 4-(6-amino-pyridin-2-yl)-cyclohexanone (as prepared in the Example 22, Step C) and N-(azetidin-3-ylcarbamoylmethyl)-4-fluoro-3-trifluoromethyl-benzamide (analog synthesis by following the procedure described in Organic Synthesis XII, 40-2, 1932) using the procedure described in Step F of Example 1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08269015B2 |
| Source dataset | uspto-grants-2012_09 |
| ORD ID | ord-f36759be0e7e4e97bf8656186f76e090 |
| Source note | uspto-grants-2012_09 |