HCID 59361623, compound → N-({1-[4-(6-Amino-pyridin-2-yl)-cyclohexyl]-azetidin-3-ylcarbamoyl}-methyl)-3-fluoro-5-trifluoromethyl-benzamide

HRID 2388319Notes

Reaction equation

HRID 2388319 reaction equation
[NH2:1][C:2]1[N:7]=[C:6]([CH:8]2[CH2:13][CH2:12][C:11](=O)[CH2:10][CH2:9]2)[CH:5]=[CH:4][CH:3]=1.[NH:15]1[CH2:18][CH:17]([NH:19][C:20]([CH2:22][NH:23][C:24](=[O:36])[C:25]2[CH:30]=[C:29]([F:31])[CH:28]=[C:27]([C:32]([F:35])([F:34])[F:33])[CH:26]=2)=[O:21])[CH2:16]1>>[NH2:1][C:2]1[N:7]=[C:6]([CH:8]2[CH2:13][CH2:12][CH:11]([N:15]3[CH2:18][CH:17]([NH:19][C:20]([CH2:22][NH:23][C:24](=[O:36])[C:25]4[CH:26]=[C:27]([C:32]([F:35])([F:33])[F:34])[CH:28]=[C:29]([F:31])[CH:30]=4)=[O:21])[CH2:16]3)[CH2:10][CH2:9]2)[CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 59361623HCID 59361623, compoundHCID 59541848HCID 59541848, compound

Product 1

HCID 46945856N-({1-[4-(6-Amino-pyridin-2-yl)-cyclohexyl]-azetidin-3-ylcarbamoyl}-methyl)-3-fluoro-5-trifluoromethyl-benzamide

Procedure

The title compounds were prepared as white solids from the reductive amination of 4-(6-amino-pyridin-2-yl)-cyclohexanone (as prepared in Example 22, Step C) and N-(azetidin-3-ylcarbamoylmethyl)-5-fluoro-3-trifluoromethyl-benzamide (analog synthesis by following the procedure described in Organic Synthesis XII, 40-2, 1932) using the procedure described in Step F of Example 1.

Workup

  1. customanalog synthesis

Sources & evidence

ORD record
ord-6501d6a9749e4c439cc7b6b9c367752c
Source dataset
uspto-grants-2012_09
Patent number
US08269015B2

Reaction notes

Loading…