HCID 66750331, compound → HCID 59541792, compound

Participants

Reaction Steps

5-(1,4-Dioxa-spiro[4.5]dec-7-en-8-yl)-1H-pyridin-2-one from Step A of Example 37 (5.2 g, 22.1 mmol) in ethyl acetate (30 mL) was treated with 5% Pd/C (Aldrich, 2.6 g) at room temperature. The reaction mixture was then charged with a hydrogen balloon and stirred for 2 hours. The catalyst was removed by filtering the reaction through a pad of Celite. The filtrate was concentrated to give the crude product, which was then purified with a CombiFlash® system using silica gel column and 40% ethyl acetate in hexanes as eluent to give the title compound as a white solid.

Provenance & Evidence