N-(azetidin-3-ylcarbamoylmethyl)-3-trifluoromethyl-benzamide → HCID 46946258, compound

HRID 2388329Notes

Reaction equation

HRID 2388329 reaction equation
[O:1]=[C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[CH2:13][CH2:12][C:11](=O)[CH2:10][CH2:9]2)=[CH:4][N:3]1[CH2:15][C:16]#[N:17].[NH:18]1[CH2:21][CH:20]([NH:22][C:23]([CH2:25][NH:26][C:27](=[O:38])[C:28]2[CH:33]=[CH:32][CH:31]=[C:30]([C:34]([F:37])([F:36])[F:35])[CH:29]=2)=[O:24])[CH2:19]1>>[C:16]([CH2:15][N:3]1[C:2](=[O:1])[CH:7]=[CH:6][C:5]([CH:8]2[CH2:13][CH2:12][CH:11]([N:18]3[CH2:21][CH:20]([NH:22][C:23]([CH2:25][NH:26][C:27](=[O:38])[C:28]4[CH:33]=[CH:32][CH:31]=[C:30]([C:34]([F:37])([F:35])[F:36])[CH:29]=4)=[O:24])[CH2:19]3)[CH2:10][CH2:9]2)=[CH:4]1)#[N:17]

Participants

3

Reactant 2

HCID 59361594N-(azetidin-3-ylcarbamoylmethyl)-3-trifluoromethyl-benzamideHCID 86646674HCID 86646674, compound

Product 1

HCID 46946258HCID 46946258, compound

Procedure

The title compounds were prepared as white solids from the reductive amination of [2-oxo-5-(4-oxo-cyclohexyl)-2H-pyridin-1-yl]-acetonitrile (as prepared in the previous step) and N-(azetidin-3-ylcarbamoylmethyl)-3-trifluoromethyl-benzamide using the procedure described in Step F of Example 1.

Sources & evidence

ORD record
ord-380f6b62369849a5b34b9a7931d1bdc6
Source dataset
uspto-grants-2012_09
Patent number
US08269015B2

Reaction notes

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