N-(azetidin-3-ylcarbamoylmethyl)-3-trifluoromethyl-benzamide → HCID 46946259, compound

HRID 2388330Notes

Reaction equation

HRID 2388330 reaction equation
O=[C:2]1[CH2:7][CH2:6][CH:5]([C:8]2[CH:9]=[CH:10][C:11](=[O:19])[N:12]([CH2:14][C:15]([F:18])([F:17])[F:16])[CH:13]=2)[CH2:4][CH2:3]1.[NH:20]1[CH2:23][CH:22]([NH:24][C:25]([CH2:27][NH:28][C:29](=[O:40])[C:30]2[CH:35]=[CH:34][CH:33]=[C:32]([C:36]([F:39])([F:38])[F:37])[CH:31]=2)=[O:26])[CH2:21]1>>[O:19]=[C:11]1[N:12]([CH2:14][C:15]([F:18])([F:17])[F:16])[CH:13]=[C:8]([CH:5]2[CH2:6][CH2:7][CH:2]([N:20]3[CH2:23][CH:22]([NH:24][C:25]([CH2:27][NH:28][C:29](=[O:40])[C:30]4[CH:35]=[CH:34][CH:33]=[C:32]([C:36]([F:39])([F:37])[F:38])[CH:31]=4)=[O:26])[CH2:21]3)[CH2:3][CH2:4]2)[CH:9]=[CH:10]1

Participants

3

Reactant 2

HCID 59361594N-(azetidin-3-ylcarbamoylmethyl)-3-trifluoromethyl-benzamideHCID 59541850HCID 59541850, compound

Product 1

HCID 46946259HCID 46946259, compound

Procedure

The title compounds were prepared as white solids from the reductive amination of 5-(4-oxo-cyclohexyl)-1-(2,2,2-trifluoro-ethyl)-1H-pyridin-2-one (as prepared in the previous step) and N-(azetidin-3-ylcarbamoylmethyl)-3-trifluoromethyl-benzamide using the procedure described in Step F of Example 1.

Sources & evidence

ORD record
ord-4f2fc764dd5445deadf3db041176ea57
Source dataset
uspto-grants-2012_09
Patent number
US08269015B2

Reaction notes

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