N-(azetidin-3-ylcarbamoylmethyl)-3-trifluoromethyl-benzamide → HCID 46946650, compound

HRID 2388345Notes

Reaction equation

HRID 2388345 reaction equation
[CH3:1][O:2][C:3](=[O:17])[NH:4][C:5]1[S:6][C:7]([CH:10]2[CH2:15][CH2:14][C:13](=O)[CH2:12][CH2:11]2)=[CH:8][N:9]=1.[NH:18]1[CH2:21][CH:20]([NH:22][C:23]([CH2:25][NH:26][C:27](=[O:38])[C:28]2[CH:33]=[CH:32][CH:31]=[C:30]([C:34]([F:37])([F:36])[F:35])[CH:29]=2)=[O:24])[CH2:19]1>>[CH3:1][O:2][C:3](=[O:17])[NH:4][C:5]1[S:6][C:7]([CH:10]2[CH2:15][CH2:14][CH:13]([N:18]3[CH2:21][CH:20]([NH:22][C:23](=[O:24])[CH2:25][NH:26][C:27](=[O:38])[C:28]4[CH:33]=[CH:32][CH:31]=[C:30]([C:34]([F:36])([F:37])[F:35])[CH:29]=4)[CH2:19]3)[CH2:12][CH2:11]2)=[CH:8][N:9]=1

Participants

3

Reactant 2

HCID 59361594N-(azetidin-3-ylcarbamoylmethyl)-3-trifluoromethyl-benzamideHCID 86646676HCID 86646676, compound

Product 1

HCID 46946650HCID 46946650, compound

Procedure

The title compounds were prepared as white solids from the reductive amination of [5-(4-oxo-cyclohexyl)-thiazol-2-yl]-carbamic acid methyl ester (as prepared in the previous step) and N-(azetidin-3-ylcarbamoylmethyl)-3-trifluoromethyl-benzamide using the procedure described in Step F of Example 1.

Sources & evidence

ORD record
ord-0a8f94dc072541e18881abbb0825a1b9
Source dataset
uspto-grants-2012_09
Patent number
US08269015B2

Reaction notes

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