N-(azetidin-3-ylcarbamoylmethyl)-3-trifluoromethyl-benzamide → HCID 46946651, compound

HRID 2388347Notes

Reaction equation

HRID 2388347 reaction equation
O=[C:2]1[CH2:7][CH2:6][CH:5]([C:8]2[S:12][C:11]([C:13]([OH:15])=[O:14])=[N:10][CH:9]=2)[CH2:4][CH2:3]1.[NH:16]1[CH2:19][CH:18]([NH:20][C:21]([CH2:23][NH:24][C:25](=[O:36])[C:26]2[CH:31]=[CH:30][CH:29]=[C:28]([C:32]([F:35])([F:34])[F:33])[CH:27]=2)=[O:22])[CH2:17]1>>[F:35][C:32]([F:33])([F:34])[C:28]1[CH:27]=[C:26]([CH:31]=[CH:30][CH:29]=1)[C:25]([NH:24][CH2:23][C:21]([NH:20][CH:18]1[CH2:19][N:16]([CH:2]2[CH2:7][CH2:6][CH:5]([C:8]3[S:12][C:11]([C:13]([OH:15])=[O:14])=[N:10][CH:9]=3)[CH2:4][CH2:3]2)[CH2:17]1)=[O:22])=[O:36]

Participants

3

Reactant 2

HCID 59361594N-(azetidin-3-ylcarbamoylmethyl)-3-trifluoromethyl-benzamideHCID 59541870HCID 59541870, compound

Product 1

HCID 46946651HCID 46946651, compound

Procedure

The title compounds were prepared as white solids from the reductive amination of 5-(4-oxo-cyclohexyl)-thiazole-2-carboxylic acid (as prepared in the previous step) and N-(azetidin-3-ylcarbamoylmethyl)-3-trifluoromethyl-benzamide using the procedure described in Step F of Example 1.

Sources & evidence

ORD record
ord-86117c246b1945318b0cf730acb3aba3
Source dataset
uspto-grants-2012_09
Patent number
US08269015B2

Reaction notes

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