N-(azetidin-3-ylcarbamoylmethyl)-3-trifluoromethyl-benzamide → HCID 46946653, compound

HRID 2388350Notes

Reaction equation

HRID 2388350 reaction equation
O=[C:2]1[CH2:7][CH2:6][CH:5]([C:8]2[S:12][C:11](=[O:13])[NH:10][CH:9]=2)[CH2:4][CH2:3]1.[NH:14]1[CH2:17][CH:16]([NH:18][C:19]([CH2:21][NH:22][C:23](=[O:34])[C:24]2[CH:29]=[CH:28][CH:27]=[C:26]([C:30]([F:33])([F:32])[F:31])[CH:25]=2)=[O:20])[CH2:15]1>>[O:13]=[C:11]1[NH:10][CH:9]=[C:8]([CH:5]2[CH2:6][CH2:7][CH:2]([N:14]3[CH2:17][CH:16]([NH:18][C:19]([CH2:21][NH:22][C:23](=[O:34])[C:24]4[CH:29]=[CH:28][CH:27]=[C:26]([C:30]([F:33])([F:31])[F:32])[CH:25]=4)=[O:20])[CH2:15]3)[CH2:3][CH2:4]2)[S:12]1

Participants

3

Reactant 2

HCID 59361594N-(azetidin-3-ylcarbamoylmethyl)-3-trifluoromethyl-benzamideHCID 59541776HCID 59541776, compound

Product 1

HCID 46946653HCID 46946653, compound

Procedure

The title compounds were prepared as white solids from the reductive amination of 5-(4-oxo-cyclohexyl)-3H-thiazol-2-one (as prepared in the previous step) and N-(azetidin-3-ylcarbamoylmethyl)-3-trifluoromethyl-benzamide using the procedure described in Step F of Example 1.

Sources & evidence

ORD record
ord-4ee6126c70a84461be3f71b4177b1444
Source dataset
uspto-grants-2012_09
Patent number
US08269015B2

Reaction notes

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