Hydrochloric Acid → HCID 178509303, compound

Participants

Reaction Steps

A solution of 4-(1,4-dioxa-spiro[4.5]dec-8-yl)-isoxazolidine-3,5-diylidenediamine (as prepared in the previous step, 0.078 g, 0.326 mmol) in acetonitrile (10 mL) was treated with 1N aqueous HCl (3.2 mL, 3.2 mmol), and stirred at ambient temperature for 6 h. After removing the MeCN in vacuo, the reaction was treated with saturated aqueous NaHCO3 (ca. 7 mL), stirred at ambient temperature overnight, and extracted thrice with EtOAc. The combined organic layers were washed with brine, dried over Na2SO4, filtered and concentrated in vacuo to give the title compound as an orange gum.

Provenance & Evidence