Ammonia → N,N-Dimethyl-3-((naphthalen-1-yl)oxy)-3-(thiophen-2-yl)propan-1-amine

Participants

Reaction Steps

Racemic N,N-dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl)propanamine oxalate salt (5, HA=oxalic acid) (15 gm) was suspended in mixture of water (100 ml) and cyclohexane (50 ml). This suspension was basified with aqueous ammonia and then layers were separated. The cyclohexane layer was washed with water and concentrated under reduced pressure to give oily mass of (±)-N,N-dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl)propanamine free base (6a+6b). Yield: 10 gm.

Provenance & Evidence