Duloxetine → Duloxetine Hydrochloride

Participants

Reaction Conditions

Reaction Steps

Duloxetine free base (35 gm) was dissolved in ethyl acetate (500 ml) and the resulting solution was cooled to 5-10° C. To this solution was added to ethyl acetate-HCl solution (about 12%) dropwise in 10-15 minutes. Slowly white solid started to precipitate out. Addition of ethyl acetate-HCl solution was continued till the pH of slurry reached between 2-3. The thick slurry mass was stirred at 15-20° C. for one hour. Solid was filtered, washed with ethyl acetate and dried under reduced pressure at 45-50° C. Yield: 35.3 gm, chemical purity: 99.8% (by HPLC) and chiral purity: 99.95% (by HPLC).

Provenance & Evidence