Duloxetine → Duloxetine Hydrochloride

Participants

Reaction Conditions

Reaction Steps

Duloxetine free base (10 gm) was dissolved in isopropyl acetate (100 ml) and cooled to 5-10° C. To this solution isopropyl alcohol-HCl solution (about 15%) was added dropwise till pH was between 2-3. The resulting thick slurry stirred at 15-20° C. for two hours. Solid was filtered, washed with isopropyl acetate (20 ml), dried under reduced pressure at 45-50° C. Yield: 8.2 gm; chemical purity: 99.8% (by HPLC) and chiral purity: 99.95%.

Provenance & Evidence