反应详情

Methyl 3-methylpyrazine-2-carboxylate (2.44 g, 16 mmol) was dissolved in chloroform (100 ml) and N-chlorosuccinimde (2.14 g, 16 mmol) was added thereto. Then, benzoyl peroxide (110 mg, 70%, 0.32 mmol) was added and refluxed under heating for 30 hours. The reaction solution was cooled, followed by removing undissolved substance by filtration. The filtrate was concentrated under reduced pressure, and the residue was purified by using silica gel chromatography (hexane:ethyl acetate=1:1)to obtain 1.55 g of the desired compound.

1. additionN-chlorosuccinimde (2.14 g, 16 mmol) was added
2. temperaturerefluxed
3. temperatureunder heating for 30 hours
4. temperatureThe reaction solution was cooled
5. customby removing undissolved substance
6. filtrationby filtration
7. concentrationThe filtrate was concentrated under reduced pressure
8. customthe residue was purified