2-Chloro-6-methylbenzene-1-sulfonyl chloride → HCID 57916244, compound

HRID 2388665Notes

Reaction equation

HRID 2388665 reaction equation
CO[C:3]1[CH:8]=[C:7](C)[C:6]([S:10]([N:13]2[CH2:18][CH2:17][CH2:16][CH2:15][C@H:14]2[CH2:19][O:20][CH2:21][C:22]([OH:24])=[O:23])(=[O:12])=[O:11])=[C:5]([CH3:25])[CH:4]=1.[Cl:26]C1C=CC=C(C)C=1S(Cl)(=O)=O>>[Cl:26][C:7]1[CH:8]=[CH:3][CH:4]=[C:5]([CH3:25])[C:6]=1[S:10]([N:13]1[CH2:18][CH2:17][CH2:16][CH2:15][C@H:14]1[CH2:19][O:20][CH2:21][C:22]([OH:24])=[O:23])(=[O:12])=[O:11]

Participants

3

Reactant 2

HCID 157253702-Chloro-6-methylbenzene-1-sulfonyl chlorideHCID 57819715(S)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)acetic acid

Product 1

HCID 57916244HCID 57916244, compound

Procedure

Synthesis of this acid unit was carried out in analogy to (S)-2-((1-(4-Methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)acetic acid (AC28) employing 2-chloro-6-methylbenzene-1-sulfonyl chloride in step (ii).

Workup

  1. customSynthesis of this acid unit

Sources & evidence

ORD record
ord-f6f9a0b2c5a140fea466de68694371ab
Source dataset
uspto-grants-2012_09
Patent number
US08268814B2

Reaction notes

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