反应详情

5-(tert-Butoxycarbonyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine-2-carbalde-hyde (440 mg, 1.65 mmol) and piperidine (0.18 ml, 1.81 mmol) were dissolved in THF (10 ml), and NaBH(OAc)3 (523 mg, 2.47 mmol) and glacial acetic acid (94 μl, 1.65 mmol) were added. This mixture was stirred under a nitrogen atmosphere at room temperature for 24 hours. The solvent was then distilled off in vacuo and the residue was taken up in ethyl acetate (25 ml). The solution obtained was washed with NaHCO3 solution and NaCl solution and the combined organic phases were dried with Na2SO4, filtered and concentrated in vacuo. The crude product (580 mg) was employed directly in the next stage without further purification.

1. distillationThe solvent was then distilled off in vacuo
2. customThe solution obtained
3. washwas washed with NaHCO3 solution and NaCl solution
4. dry with materialthe combined organic phases were dried with Na2SO4
5. filtrationfiltered
6. concentrationconcentrated in vacuo
7. customThe crude product (580 mg) was employed directly in the next stage without further purification