HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2388679Generated: November 1, 2026
Hydrochloric Acid → 4,5,6,7-Tetrahydrothieno[3,2-c]pyridine-2-carboxylic acid hydrochloride
https://huagongshe.com/reaction/2388679
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Diethyl 6,7-dihydrothieno[3,2-c]pyridine-2,5(4H)-dicarboxylate | HCID 14254905 | — |
| Solvent | Potassium Hydroxide | HCID 14797 | — |
| Product | 4,5,6,7-Tetrahydrothieno[3,2-c]pyridine-2-carboxylic acid hydrochloride | HCID 68643989 | 30% |
Reaction Steps
Diethyl 6,7-dihydrothieno[3,2-c]pyridine-2,5(4H)-dicarboxylate (1.76 mmol) in 3.5 N KOH solution (3 ml) was refluxed for 3 h (monitored by TLC). The reaction mixture was cooled to 0° C. and acidified with conc. HCl. The solid was collected by filtration and dried to give the desired product. Yield: 30%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08268814B2 |
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| Source dataset | uspto-grants-2012_09 |
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| ORD ID | ord-e903220b56f14803b324aa1a040c7202 |
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| Source note | uspto-grants-2012_09 |
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