Water → tert-Butyl 4-(pyrrolidin-1-yl)-3,6-dihydropyridine-1(2H)-carboxylate

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Reaction Steps

Catalytic amounts of p-toluenesulfonic acid (0.47 g, 0.27 mmol) were added to a solution of N-Boc-4-piperidone (5 g, 25.12 mmol) and pyrrolidine (1.96 g, 27.63 mmol) in toluene (100 ml) and the mixture was stirred under reflux for 2 hours, using a water separator. The solution formed was concentrated to dryness in vacuo and the residue obtained was employed directly in the next stage.

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