HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2388707Generated: November 2, 2026
Hydrochloric Acid → 4,5,6,7-Tetrahydro-thiazolo[5,4-c]pyridine-2-carboxylic acid dihydrochloride
https://huagongshe.com/reaction/2388707
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | HCID 68643988 | HCID 68643988 | — |
| Solvent | Potassium Hydroxide | HCID 14797 | — |
| Product | 4,5,6,7-Tetrahydro-thiazolo[5,4-c]pyridine-2-carboxylic acid dihydrochloride | HCID 68643955 | 60% |
Reaction Steps
Diethyl 6,7-dihydrothiazolo[5,4-c]pyridine-2,5(4H)-dicarboxylate (1.76 mmol) in 3.5 N KOH solution (3 ml) was refluxed for 3 h (monitored by TLC). The reaction mixture was cooled to 0° C. and acidified with conc. HCl. The solid was collected by filtration and dried to yield the desired product. Yield: 60%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08268814B2 |
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| Source dataset | uspto-grants-2012_09 |
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| ORD ID | ord-6296e09437c244a58b3c146934877e6e |
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| Source note | uspto-grants-2012_09 |
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