HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-(4-methyl-5-sulfamoylthiazol-2-yl)acetamide → 2-Amino-4-methyl-1,3-thiazole-5-sulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-(4-methyl-5-sulfamoylthiazol-2-yl)acetamide | HCID 3244062 | — |
| Reactant | N-{5-[({2-[(2,3-Difluorobenzyl)thio]-6-methoxypyrimidin-4-yl)amino)sulfonyl]-4-methyl-1,3-thiazol-2-yl]acetamide | HCID 59558795 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Hydrazine hydrate (1:1) | HCID 24654 | — |
| Product | 2-Amino-4-methyl-1,3-thiazole-5-sulfonamide | HCID 18693244 | — |
Reaction Steps
A suspension of N-[5-(aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]acetamide (the product from Example 53, step (0.44 g) in hydrazine hydrate (1.5 ml) was stirred at room temperature for 4 h. The mixture was diluted with H2O and extracted with EtOAc (×4). The combined organic extracts were dried (MgSO4), filtered and evaporated to give the subtitle compound as an off-white solid. Yield 0.23 g.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08269002B2 |
| Source dataset | uspto-grants-2012_09 |
| ORD ID | ord-30286492fffc497d981a09434d72f1e7 |
| Source note | uspto-grants-2012_09 |