Sodium Hydroxide → HCID 25027863, compound

Participants

Reaction Steps

0.13 g 2-methyl-2-{[1-(4-trifluoromethoxy-benzyloxy)-5,6,7,8-tetrahydro-naphthalene-2-carbonyl]-amino}-propionic acid methyl ester was dissolved in 5 ml of tetrahydrofuran and 0.5 ml of methanol. To this was added 0.42 ml of 2 M NaOH (aq), and the reaction was stirred overnight at room temperature. The reaction mixture was concentrated in vacuo, diluted with 5 ml of ethyl acetate and 5 ml of water and acidified to pH 3 with 1N HCl (aq). The organic layer was separated, dried over magnesium sulphate and concentrated in vacuo to give 99 mg of 2-methyl-2-{[1-(4-trifluoromethoxy-benzyloxy)-5,6,7,8-tetrahydro-naphthalene-2-carbonyl]-amino}-propionic acid.

Provenance & Evidence