反应详情

温度

0 °C

3,5-Dichloropyridine-4-carboxylic acid chloride (0.54 g, 2.6 mmol) was dissolved in CH2Cl2 (2.6 mL, 2.6 mmol) and NH3 (2.0 M in dioxane) (6.5 mL) was added. The reaction mixture was cooled to 0° C. for 30 min. The residue was quenched with water and extracted with EtOAc. The organic layer was washed with brine, dried over anhydrous MgSO4 and concentrated in vacuo. The crude product was purified by preparative HPLC on silica gel to yield 3,5-dichloropyridine-4-carboxamide (0.135 g).

1. customThe residue was quenched with water
2. extractionextracted with EtOAc
3. washThe organic layer was washed with brine
4. dry with materialdried over anhydrous MgSO4
5. concentrationconcentrated in vacuo
6. customThe crude product was purified by preparative HPLC on silica gel