Hydrochloric Acid → HCID 25027408, compound

Participants

Reaction Conditions

Reaction Steps

308 mg 2-methyl-2-{[7-(4-trifluoromethyl-benzyloxy)-benzo[b]thiophene-6-carbonyl]-amino}-propionic acid methyl ester was dissolved in 5 ml of 1,4-dioxane. To this was added 3.4 ml of 1 M LiOH (aq), and the reaction was stirred for 1 h at 60° C. and overnight at room temperature. The reaction mixture was diluted with 10 ml of ethyl acetate, acidified to pH 3 with 2N HCl (aq) and extracted with 10 ml ethyl acetate four times. The combined organic layers were washed with brine, dried over sodium sulphate and concentrated in vacuo to give 299 mg of 2-methyl-2-{[7-(4-trifluoromethyl-benzyloxy)-benzo[b]thiophene-6-carbonyl]-amino}-propionic acid.

Provenance & Evidence