2-(Bromomethyl)-5-(trifluoromethyl)pyridine → HCID 25027406, compound

Participants

Reaction Steps

2-Methyl-2-{[4-(5-trifluoromethyl-pyridin-2-ylmethoxy)-benzo[b]thiophene-5-carbonyl]-amino}-propionic acid was prepared in analogy to example 13 via a sequence of an alkylation reaction of 2-[(4-Hydroxy-benzo[b]thiophene-5-carbonyl)-amino]-2-methyl-propionic acid tert-butyl ester using 2-bromomethyl-5-trifluoromethyl-pyridine and an acidic hydrolysis of the amino acid ester to the free amino acid

Provenance & Evidence