HCID 69032396, compound → HCID 86605613, compound

Participants

Reaction Steps

4-Benzyloxy-1,2,3-tri(tert-butyldimethylsilyloxy)-L-threitol (5.9 g, 10.6 mmol) dissolved in EtOAc (70 mL) was hydrogenated (balloon as H2 container) in the presence of 10% Pd/C (1 g) until no more starting material could be detected on TLC plate (about 5 h). The catalyst was removed by filtration through a Celite pad, with rinsing the solid with EtOAc. The filtrate was evaporated to dryness, and the residue was purified by silica gel flash chromatography (eluting with 10% ether in hexanes) to give 1,2,3-tri(tert-butyldimethylsilyloxy)-L-threitol (2.1 g, 41% yield).

Provenance & Evidence