Isopropyl 6-bromohexanoate → 1-Benzyl-2-phenyl-6-[(5-(iso-propyl-oxycarbonyl)pentyl]oxy]-benzimidazole

HRID 23890Notes

Reaction equation

HRID 23890 reaction equation
[CH2:1]([N:8]1[C:12]2[CH:13]=[C:14]([OH:17])[CH:15]=[CH:16][C:11]=2[N:10]=[C:9]1[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH:24]([O:27][C:28](=[O:35])[CH2:29][CH2:30][CH2:31][CH2:32][CH2:33]Br)([CH3:26])[CH3:25]>>[CH2:1]([N:8]1[C:12]2[CH:13]=[C:14]([O:17][CH2:33][CH2:32][CH2:31][CH2:30][CH2:29][C:28]([O:27][CH:24]([CH3:25])[CH3:26])=[O:35])[CH:15]=[CH:16][C:11]=2[N:10]=[C:9]1[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 549816Isopropyl 6-bromohexanoateHCID 22569939HCID 22569939, compound

Product 1

HCID 120509761-Benzyl-2-phenyl-6-[(5-(iso-propyl-oxycarbonyl)pentyl]oxy]-benzimidazole

Procedure

1-Benzyl-6-hydroxy-2-phenylbenzimidazole is alkylated according to general operating instructions 2 with 6-bromo-hexanoic acid isopropyl ester. 1-Benzyl-2-phenyl-6-[(5-(iso-propyl-oxycarbonyl)pentyl]oxy]-benzimidazole is obtained as a resin.

Sources & evidence

ORD record
ord-2c57fbc46f99407fad506d89d5f65f75
Source dataset
uspto-grants-2005_02
Patent number
US06855714B2

Reaction notes

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