Ethanol → HCID 46196230, compound

Participants

Reaction Steps

The compound was prepared in a manner similar as to that described above using (R)-4-[6-(Bicyclohexyl-4-yloxy)-naphthalen-2-yl]-4-methyl-oxazolidin-2-one (200 mg, 0.0005 mol), ethanol (2.2 g, 0.049 mol), and 4.2 M lithium hydroxide, monohydrate in water (2.1 mL, 0.0090 mol) to give 46 mg of the desired product as a white solid (46%). ESI-MS: 365 (M-16)+. 1H NMR (400 MHz, CDCl3) δ=7.99-7.55 (m, 3 H), 7.29-7.12 (m, 1 H), 7.08 (s, 2 H), 4.70 (s, 1 H), 4.32-4.17 (m, 1 H), 3.27-2.99 (m, 2 H), 2.32-0.81 (m, 25 H).

Provenance & Evidence