Ethanol → HCID 46196242, compound

Participants

Reaction Steps

The compound was prepared in a manner similar as to that described above using (R)-4-[6-(4-Cyclopentyl-cyclohexyloxy)-naphthalen-2-yl]-4-methyl-oxazolidin-2-one (200 mg, 0.0005 mol), ethanol (2.2 g, 0.049 mol), 4.2 M lithium hydroxide, monohydrate in water (2.1 mL, 0.0090 mol) to give 114 mg the desired product as a white solid (90%). ESI-MS: 351 (M+H)+. 1H NMR (400 MHz, DMSO-d6) δ=7.87 (s, 1 H), 7.81-7.55 (m, 3 H), 7.31-7.21 (m, 1 H), 7.18-7.00 (m, 1 H), 4.98-4.59 (m, 3 H), 4.43-4.27 (m, 0.63 H), 3.57-3.14 (m, 4 H), 2.19-0.84 (m, 17 H)

Provenance & Evidence