Acetic Acid → HCID 46196245, compound

Participants

Reaction Steps

[(R)-1-[6-(4-Cyclopentyl-cyclohexyloxy)-5-trifluoromethyl-naphthalen-2-yl]-2-(di-tert-butoxy-phosphoryloxy)-1-methyl-ethyl]-carbamic acid tert-butyl ester (11 mg, 0.000015 mol) was added 12 M of hydrogen chloride in water (1 mL, 0.01 mol; Supplier=Aldrich) and acetic acid (1 mL, 0.02 mol) and the solution was stirred for 1.5 h at RT. All solvent was then removed inder reduced pressure and the residue was dried on high-vac over night to give the desired product 8 mg was a white HCl salt (98%). ESI-MS: 499 (M-16)+. 1H NMR (400 MHz, DMSO-d6) δ=8.19-8.07 (m, 1 H), 7.84 (d, J=9.0 Hz, 1 H), 7.63-7.42 (m, 2 H), 7.22 (dd, J=5.0, 9.0 Hz, 1 H), 5.10 (br. s., 1 H), 4.32-4.11 (m, 1 H), 3.72 (m, 2 H), 2.18-1.98 (m, 2 H), 1.92-0.71 (m, 21 H)

Provenance & Evidence