HCID 178435547, compound → HCID 178435533, compound

HRID 2389132Notes

Reaction equation

[C:1]([C@H:5]1[CH2:10][CH2:9][C@H:8]([O:11][C:12]2[CH:21]=[CH:20][C:19]3[C:14](=[CH:15][CH:16]=[C:17]([CH:22]([N+:24]([O-:26])=[O:25])[CH3:23])[CH:18]=3)[CH:13]=2)[CH2:7][CH2:6]1)([CH3:4])([CH3:3])[CH3:2].BrC1C=C2C(=CC=1)C([C:38]([F:41])([F:40])[F:39])=C(O[C@H]1CC[C@H](C(C)(C)C)CC1)C=C2>>[C:1]([C@H:5]1[CH2:10][CH2:9][C@H:8]([O:11][C:12]2[CH:21]=[CH:20][C:19]3[C:14](=[CH:15][CH:16]=[C:17]([CH:22]([N+:24]([O-:26])=[O:25])[CH3:23])[CH:18]=3)[C:13]=2[C:38]([F:41])([F:40])[F:39])[CH2:7][CH2:6]1)([CH3:2])([CH3:3])[CH3:4]

Participants

Reactant 2

HCID 178435547HCID 178435547, compound

HCID 178445719HCID 178445719, compound

Product 1

HCID 178435533HCID 178435533, compoundYield 35%

Procedure

2-(trans-4-tert-butylcyclohexyloxy)-6-(1-nitroethyl)-1-(trifluoromethyl)naphthalene was synthesized as per 2-(trans-4-tert-butylcyclohexyloxy)-6-(1-nitroethyl)naphthalene (Example 204) in 35% yield using 6-bromo-2-(trans-4-tert-butylcyclohexyloxy)-1-(trifluoromethyl)naphthalene as starting material.

Sources & evidence

ORD record: ord-a217e29f94234d0bb0e25ca6c814cc80
Source dataset: uspto-grants-2012_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08269043B2

Reaction notes

Loading…