HCID 178435533, compound → HCID 178500160, compound

HRID 2389133Notes

Reaction equation

[C:1]([C@H:5]1[CH2:10][CH2:9][C@H:8]([O:11][C:12]2[CH:13]=[C:14]3[C:19](=[CH:20][CH:21]=2)[CH:18]=[C:17]([C:22]([N+:30]([O-:32])=[O:31])([CH3:29])[CH2:23][CH2:24][C:25]([O:27][CH3:28])=[O:26])[CH:16]=[CH:15]3)[CH2:7][CH2:6]1)([CH3:4])([CH3:3])[CH3:2].C([C@H]1CC[C@H](OC2C=CC3C(=CC=C(C([N+]([O-])=O)C)C=3)C=2[C:59]([F:62])([F:61])[F:60])CC1)(C)(C)C>>[C:1]([C@H:5]1[CH2:6][CH2:7][C@H:8]([O:11][C:12]2[C:13]([C:59]([F:62])([F:61])[F:60])=[C:14]3[C:19](=[CH:20][CH:21]=2)[CH:18]=[C:17]([C:22]([N+:30]([O-:32])=[O:31])([CH3:29])[CH2:23][CH2:24][C:25]([O:27][CH3:28])=[O:26])[CH:16]=[CH:15]3)[CH2:9][CH2:10]1)([CH3:4])([CH3:2])[CH3:3]

Participants

Reactant 2

HCID 178435533HCID 178435533, compound

HCID 178500163HCID 178500163, compound

Product 1

HCID 178500160HCID 178500160, compoundYield 62%

Procedure

Methyl 4-(6-(trans-4-tert-butylcyclohexyloxy)-5-(trifluoromethyl)naphthalen-2-yl)-4-nitropentanoate was synthesized as per methyl 4-(6-(trans-4-tert-butylcyclohexyloxy)naphthalen-2-yl)-4-nitropentanoate (Example 205) in 62% yield using 2-(trans-4-tert-butylcyclohexyloxy)-6-(1-nitroethyl)-1-(trifluoromethyl)naphthalene as starting material.

Sources & evidence

ORD record: ord-3c10a70bdfcf44829990ae4867a83a0f
Source dataset: uspto-grants-2012_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08269043B2

Reaction notes

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