HRID2389133

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(c1ccc2c(C(F)(F)F)c(O[C@H]3CC[C@H](C(C)(C)C)CC3)ccc2c1)[N+](=O)[O-]

HCID178435533

未命名化合物

结构：COC(=O)CCC(C)(c1ccc2cc(O[C@H]3CC[C@H](C(C)(C)C)CC3)ccc2c1)[N+](=O)[O-]

HCID178500163

未命名化合物

PRODUCTS

生成物

结构：COC(=O)CCC(C)(c1ccc2c(C(F)(F)F)c(O[C@H]3CC[C@H](C(C)(C)C)CC3)ccc2c1)[N+](=O)[O-]

HCID178500160

未命名化合物

收率 62%

PROCEDURE

实验过程

Methyl 4-(6-(trans-4-tert-butylcyclohexyloxy)-5-(trifluoromethyl)naphthalen-2-yl)-4-nitropentanoate was synthesized as per methyl 4-(6-(trans-4-tert-butylcyclohexyloxy)naphthalen-2-yl)-4-nitropentanoate (Example 205) in 62% yield using 2-(trans-4-tert-butylcyclohexyloxy)-6-(1-nitroethyl)-1-(trifluoromethyl)naphthalene as starting material.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-3c10a70bdfcf44829990ae4867a83a0f
来源数据集: uspto-grants-2012_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08269043B2
来源说明: uspto-grants-2012_09

反应 SMILES

[C:1]([C@H:5]1[CH2:10][CH2:9][C@H:8]([O:11][C:12]2[CH:13]=[C:14]3[C:19](=[CH:20][CH:21]=2)[CH:18]=[C:17]([C:22]([N+:30]([O-:32])=[O:31])([CH3:29])[CH2:23][CH2:24][C:25]([O:27][CH3:28])=[O:26])[CH:16]=[CH:15]3)[CH2:7][CH2:6]1)([CH3:4])([CH3:3])[CH3:2].C([C@H]1CC[C@H](OC2C=CC3C(=CC=C(C([N+]([O-])=O)C)C=3)C=2[C:59]([F:62])([F:61])[F:60])CC1)(C)(C)C>>[C:1]([C@H:5]1[CH2:6][CH2:7][C@H:8]([O:11][C:12]2[C:13]([C:59]([F:62])([F:61])[F:60])=[C:14]3[C:19](=[CH:20][CH:21]=2)[CH:18]=[C:17]([C:22]([N+:30]([O-:32])=[O:31])([CH3:29])[CH2:23][CH2:24][C:25]([O:27][CH3:28])=[O:26])[CH:16]=[CH:15]3)[CH2:9][CH2:10]1)([CH3:4])([CH3:2])[CH3:3]