HCID 178445751, compound → HCID 178445810, compound

Participants

Reaction Steps

(R)-2-amino-2-(6-(trans-4-tert-butylcyclohexyloxy)-5,7,8-trichloronaphthalen-2-yl)propan-1-ol was synthesized as per (R)-2-amino-2-(6-(trans-4-tert-butylcyclohexyloxy)-5-(4-(trifluoromethoxy)phenyl)naphthalen-2-yl)propan-1-ol (Example 221) in 37% yield using (R)-4-(6-(trans-4-tert-butylcyclohexyloxy)-5,7,8-trichloronaphthalen-2-yl)-4-methyloxazolidin-2-one as starting material. MS: m/z=441.25 [M-NH2]+. 1H NMR (MeOD) δ: 8.42 (d, J=1.5 Hz, 1H), 8.28 (d, J=9.5 Hz, 1H), 7.89 (dd, J=9.0, 2.0 Hz, 1H), 4.31-4.42 (m, 1H), 3.78 (d, J=11.0 Hz, 1H), 3.72 (d, J=11.0 Hz, 1H), 2.14-2.22 (m, 2H), 1.85-1.93 (m, 2H), 1.63-1.76 (m, 2H), 1.56 (s, 3H), 1.04-1.15 (m, 3H), 0.90 (s, 9H)

Provenance & Evidence