2-Amino-2-(6-(4-phenoxyphenoxy)naphthalen-2-yl)propane-1,3-diol → 2-Amino-2-(6-(4-(benzyloxy)phenoxy)naphthalen-2-yl)propane-1,3-diol

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Reaction Steps

2-amino-2-(6-(4-(benzyloxy)phenoxy)naphthalen-2-yl)propane-1,3-diol was synthesized as per 2-amino-2-(6-(4-phenoxyphenoxy)naphthalen-2-yl)propane-1,3-diol (Example 245) in 81% yield using 5-(6-(4-(benzyloxy)phenoxy)naphthalen-2-yl)-2,2-dimethyl-1,3-dioxan-5-amine as starting material. MS: m/z=438.24 [M+Na+]. 1H NMR (MeOD) δ: 7.95 (s, 1H), 7.87 (d, J=9.0 Hz, 1H), 7.66-7.70 (m, 1H), 7.59-7.63 (m, 1H), 7.47 (d, J=7.5 Hz, 2H), 7.37-7.43 (m, 2H), 7.34 (d, J=7.0 Hz, 1H), 7.22 (dd, J=8.8, 2.5 Hz, 1H), 7.15 (d, J=2.3 Hz, 1H), 7.00-7.08 (m, 4H), 5.11 (s, 2H), 3.87-3.93 (m, 2H), 3.80-3.86 (m, 2H)

Provenance & Evidence