反应详情

2-amino-2-(6-(4-(pentyloxy)phenoxy)naphthalen-2-yl)propane-1,3-diol was synthesized as per 2-amino-2-(6-(4-phenoxyphenoxy)naphthalen-2-yl)propane-1,3-diol (Example 245) in 55% yield using 2,2-dimethyl-5-(6-(4-(pentyloxy)phenoxy)naphthalen-2-yl)-1,3-dioxan-5-amine as starting material. MS: m/z=418.45 [M+Na+]. 1H NMR (MeOD) δ: 7.88-7.94 (m, 2H), 7.78 (d, J=8.8 Hz, 1H), 7.51 (dd, J=8.8, 2.0 Hz, 1H), 7.30 (dd, J=9.0, 2.5 Hz, 1H), 7.17 (d, J=2.3 Hz, 1H), 7.01-7.07 (m, 2H), 6.94-7.01 (m, 2H), 4.05-4.12 (m, 2H), 3.96-4.02 (m, 4H), 1.70-1.85 (m, 2H), 1.37-1.54 (m, 4H), 0.92-1.01 (m, 3H)