HCID 178421567, compound → HCID 178464712, compound

Participants

Reaction Steps

(R)-2-Amino-2-[5-trifluoromethyl-6-(trans-4-trifluoromethyl-cyclohexyloxy)-naphthalen-2-yl]-propan-1-ol was synthesized as per (R)-2-Amino-2-[6-(cis-4-trifluoromethyl-cyclohexyloxy)-naphthalen-2-yl]-propan-1-ol (Example 259) in 75% yield, using (R)-4-Methyl-4-[5-trifluoromethyl-6-(trans-4-trifluoromethyl-cyclohexyloxy)-naphthalen-2-yl]-oxazolidin-2-one as starting material. MS: m/z=458.20 [M+Na]+. 1H NMR (400 MHz, CHLOROFORM-d) δ ppm: 8.15 (dd, J=9.4, 1.6 Hz, 1H), 8.09 (d, J=9.3 Hz, 1H), 7.98 (d, J=2.0 Hz, 1H), 7.73 (dd, J=9.3, 2.3 Hz, 1H), 7.52 (d, J=9.0 Hz, 1H), 4.48-4.61 (m, 1H), 3.75 (d, J=11.0 Hz, 1H), 3.67-3.73 (m, 1H), 2.16-2.34 (m, 3H), 2.01-2.13 (m, 2H), 1.45-1.71 (m, 7H).

Provenance & Evidence