Hydrochloric Acid → HCID 178465496, compound

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Phosphoric acid mono-{(R)-2-amino-2-[5-trifluoromethyl-6-(trans-4-trifluoromethyl-cyclohexyloxy)-naphthalen-2-yl]-propyl}ester was synthesized as per Phosphoric acid mono-{(R)-2-amino-2-[6-(trans-4-trifluoromethyl-cyclohexyloxy)-naphthalen-2-yl]-propyl} ester (Example 263) in 89% yield as HCl salt, using {(R)-2-(Di-tert-butoxy-phosphoryloxy)-1-methyl-1-[5-trifluoromethyl-6-(trans-4-trifluoromethyl-cyclohexyloxy)-naphthalen-2-yl]-ethyl}-carbamic acid tert-butyl ester as starting material. MS: m/z=516.30 [M+H]+. 1H NMR (400 MHz, METHANOL-d4) δ ppm: 8.26 (dd, J=9.4, 1.4 Hz, 1H), 8.16 (d, J=9.3 Hz, 1H), 8.02 (d, J=2.3 Hz, 1H), 7.72 (dd, J=9.3, 2.3 Hz, 1H), 7.63 (d, J=9.3 Hz, 1H), 4.55-4.66 (m, 1H), 4.31 (dd, J=11.3, 4.8 Hz, 1H), 4.17 (dd, J=11.2, 5.1 Hz, 1H), 2.20-2.34 (m, 3H), 2.02-2.12 (m, 2H), 1.86 (s, 3H), 1.49-1.72 (m, 4H).

Provenance & Evidence